Emel Akdogan

Picture of Emel Akdogan
  • Grad Group: Biochemistry, Molecular, Cellular and Developmental Biology
  • Major Professor: Sean Collins
  • Lab Phone: 5307527469
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Degrees

  • B.S. - Middle East Technical University (METU), Ankara, Turkey - Molecular Biology and Genetics - 2013
  • M.S. - Koc University, Istanbul, Turkey - Molecular Biology and Genetics - 2015

Research Interest Summary

Cell and Membrane Biology, Cell Motility and the Cytoskeleton, Signal Transduction

Research Interests

Neutrophils are the first cells acutely recruited to inflammatory sites. This effective response achieved by the rapid, directed migration of neutrophils toward the chemical signals is referred to as neutrophil chemotaxis, and defects in this process are critically linked to human disease. Our lab focuses on understanding the complex biology of neutrophil chemotaxis to identify druggable targets to specifically control different behaviors of these cells during migration. Neutrophil chemotaxis is initiated via recognition of chemoattractants by a specialized subfamily of G-protein-coupled receptors (GPCRs), and I am particularly interested in how the chemoattractant receptor internalization and trafficking are regulated and contribute to this process.

Publications

  • S.M. Lundgren*, B.L. Rocha-Gregg*, E. Akdoğan, M. N. Mysore, S.L. Hayes, S.R. Collins. (2022). Signaling dynamics distinguish high and low priority neutrophil attractant receptors. Avaliable at bioRxiv: 2022.05.26.493652; doi: https://doi.org/10.1101/2022.05.26.493652
  • G.R.R. Bell, E. Rincón, E. Akdoğan, S.R. Collins. (2021). Optogenetic control of receptors reveals distinct roles for actin- and Cdc42-dependent negative signals in chemotactic signal processing. Nat Commun 12, 6148. https://doi.org/10.1038/s41467-021-26371-z
  • G.Lutfullahoğlu-Bal, A.B. Seferoğlu, A. Keskin, E. Akdoğan, and C.D. Dunn. (2018). A bacteria-derived tail anchor localizes to peroxisomes in yeast and mammalian cells. Scientific Reports. 8(1): 16374. PMID: 30401812.
  • A. Keskin, E. Akdoğan, and C.D. Dunn. (2017). Evidence for Amino Acid Snorkeling from a High Resolution, In Vivo Analysis of Fis1 Tail Anchor Insertion at the Mitochondrial Outer Membrane. Genetics. 205(2): 691-705. PMID: 28007883.
  • E. Akdoğan, M. Tardu, G. Garipler, G. Baytek, I.H. Kavakli, C.D. Dunn. (2016). Reduced Glucose Sensation Can Increase the Fitness of Saccharomyces cerevisiae Lacking Mitochondrial DNA. PLoS ONE. 11(1): e0146511. PMID: 26751567.
  • Ş.T. Örs, E. Akdoğan, and C.D. Dunn. (2014). Mutation of the mitochondrial large ribosomal RNA can provide pentamidine resistance to Saccharomyces cerevisiae. Mitochondrion. 18: 7-11. PMID: 25151477.
  • N. Mutlu, G. Garipler, E. Akdoğan, and C.D. Dunn. (2014). Activation of the Pleiotropic Drug Resistance Pathway Can Promote Mitochondrial DNA Retention by Fusion-Defective Mitochondria in Saccharomyces cerevisiae. G3. 4(7): 1247-58. PMID: 24807265.